Feed additive bile acid

Specification

Function

1. Improve the utilization of fat, prevent nutritive diarrhea and reduce feed cost.
2. Promote bile secretion, protect liver and gallbladder, prevent fatty liver disease.
3. Decompose and eliminate endotoxin, promote immunity.
4. Promote the absorption of fat and fat soluble vitamins.
5. Stabilize feed quality, reduce hazards of DDGS, or other anti-nutrition elements.
6. Increase daily weight gain, reduce feed to meat ratio, promote animals' growth.

Action Mechanism

Promote the digestion and absorption of fat and fat soluble substance

1. Emulsify fats and expand contact area with lipase
Bile acid have biosurfactant amphiphilic molecule structure with hydrophilic (hydroxyl, carboxyl) and hydrophobic (alkyl), have strong surface activity, which can effectively emulsifies fat into lipid droplets or chylomicron and improves the solubility of insoluble substances such as cholesterol in water.
When hydrophobic end break the large fat into small oil droplets, the hydrophilic end will wrap around small oil droplets, make fat infused into the water to finish fat hydrolyzation process. So bile acid greatly enlarge the contact area fat and lipase, convenient for fat digestion.
2. Regulate the activity of pancreatic lipase (LPS) and lipoprotein lipase (LPL) to promote the hydrolysis metabolism of fat 
The spatial structure of pancreatic lipase has three cap domains covering its catalytic sites. Bile acid can change this structure and expose the active site to the substrate and play its lipodysis role, so bile acid can activate the activity of pancreatic lipase to promote the hydrolysis metabolism of fat.
The apolipoprotein contained in chylomicron emulsified by bile acid can improve the activity of lipoprotein lipase therby greatly increase the hydrolysis metabolism of fat.
3. Transport fat in the intestinal and promote fat absorption
Bile acids can combine with all decomposed products of fats in the intestinal cavity such as fatty acid, monoglyceride etc. to form a water-soluble mixed micelle. 
The mixed micelle carries all fat decomposed products, large amount of fat-soluble vitamins, carotenoids and other nutrients to reach to surface of small intestinal villus and get into bloodstream, where they are absorbed.
So bile acid serve as necessary carrier for the insoluble fat hydrolysates to reach the intestinal mucosal surface and is important for the absorption of fat decomposed products.
4. Reduce the decomposition of autogenous fat
Hormone-sensitive lipase (HSL) is a rate-limiting enzyme for degradation of autogenous fat.
Bile acids can significantly reduce the activity of hormone-sensitive lipase thereby lower catabolism of autogenous fat, so it significantly reduced the catabolism of autologous fat by regulating the activity of hormone-sensitive lipase.

Protect liver and gallbladder health

1. Prevent fatty liver
Bile acid can transport fat and cholesterol, reduce the accumulation of fat in the liver, promote the compound of VLDL (very low density lipoprotein) and prevent liver diseases such as fatty liver, hepatobiliary syndrome, biliary obstruction and so on.
2. Promote bile secretion
Promote the bile secretion, unimpeded biliary and reduce the burden of liver synthesis bile acid, let the liver rest more.
3. Eliminate toxin
The liver is plagued by mycotoxins (aflatoxin, gibalenone, T-2 toxin, vomiting toxin, etc.), endotoxins (the main component is lipopolysaccharide, which is the remaining cell wall component after the killing of Gram-negative bacteria.) and heavy metals (arsenic, mercury, copper, zinc etc.) for a long time, and its own health is constantly deteriorating. Bile acid can bind and break down endotoxins, relieve the burden of liver and intestines. Help liver detoxification, provide a safe and healthy environment for liver cells, protect liver cells from the invasion of toxins such as mycotoxins, algal toxins, heavy metal ions and drug toxins so on.
4. Promote liver development
Bile acid can improve the digestion, absorption and utilization of fat and provide lipid nutrition for the development of hepatopancreas.
5. Restore liver and pancreas
Bile acid can activate insulin activity, activate thyroxine activity, effectively promote fat burning energy supply, reduce protein loss, promote liver cell repair, and enhance immune protein synthesis
6. Regulate cholesterol metabolism
Bile acid can accelerate the transfer of cholesterol in HDL (high densitylipoprotein), maintain the balance of cholesterol in animal body, and regulate cholesterol metabolism. One third of cholesterol catabolism is achieved through the synthesis of bile acid, which provides an important excretory pathway for cholesterol metabolism.
7. Antioxidant and anti-stress
Bile acid can enhance the activity of SOD (superoxide dismutase), glutathione peroxidase (GSH) and glutathione reductase (GSR), eliminate free radicals in animals’ body and improve the anti-stress ability of animal, resist lipid oxidation and protect hepatopancreas.
8. Promote the growth
Bile acid can increase the level of the main substance IGF-I that regulates animal growth and the main factor GH that promotes cell protein synthesis and cell growth in animal blood, promotes animal growth.

Bile acid circulation

The bile acids are emulsified into glycerol and fatty acids in the small intestine to form the fatty acid-bile salt complex, which is absorbed by the chorionic membrane of the small intestine and separated from the fatty acids, and then transported into the liver through the portal vein. After uptake by liver cells, the free bile acids are synthesized and combined bile acids are discharged into the intestine to complete a hepatointestinal circulation.

Why we choose bile acid?

1. High fat and energy large amount of various unconventinal materials bring heavy burden to the body organs, especially to liver and seriously affect its normal functions.
2. For young animals, immature functions of liver and gall, the concentration of bile acids is hardly reached or not enough to required concentration level, the secretion will be less under stress, leads to intestinal disease such as diarrhea etc.
3. Toxin and hazardous substances such as MDA, mycotocins and heavy metals do harm intestine, reducing utilization of nutrients and destroy liver functions. 
4. Although adult animals have relative mature digestive system, As there are high fat and energy content in diet, which go beyond the capability of liver and cause inadequate secretion of bile acids. Low utilization not only waste energy but also results in metabolism disease which affect animal health and growth performance

Application

This product is suitable for all animals such as pig, poultry, ruminant and aquatic animal, used as functional feed additives: fatty emulsifier, functional intestine promoter.

The recommended dosage of 30% bile acid as follows:

Packaging and storage

Delivery and transport

Port of loading: Qingdao or any port of China as requirements
Lead time: 10-20 days shipment after signed contract

General speaking, EMS, TNT, DHL, UPS by express, by air and by sea is main shipping terms.
By express for quantity less than 50kg cargo, also called DDU service.
By sea for quantity over 500kg.
By air is available for above 50kg.
For high value products, please select air shipping or DHL express for safe.
If the cargo quantity is more than 500kg, but by sea can not arrive at you, please select land transportation, by train or by motor.